AZD3839

  • Chemical Properties
CAS No. 1227163-56-5 Cat. No. BCP13212
Name AZD3839
Synonyms AZD 3839;AZD-3839;
Formula C24H15F4N5 M. Wt 449.41
  • Biological Activity
Description AZD3839 is a potent and selective BACE1 inhibitor. AZD3839 is clinical candidate for the treatment of Alzheimer disease. AZD3839 inhibits BACE1 activity, Aβ and sAPPβ release from modified and wild-type human SH-SY5Y cells and mouse N2A cells as well as from mouse and guinea pig primary cortical neurons. Selectivity against BACE2 and cathepsin D was 14 and >1000-fold, respectively. AZD3839 exhibits dose- and time-dependent lowering of plasma, brain, and cerebrospinal fluid Aβ levels in mouse, guinea pig, and non-human primate. AZD3839 effectively reduces the levels of Aβ in brain, CSF, and plasma in several preclinical species.
Pathways Neuro Signaling Pathway 
Targets Beta secretase 

Structure

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