Methotrexate disodium salt

  • Chemical Properties
CAS No. 7413-34-5 Cat. No. BCP13700
Name Methotrexate disodium salt
Synonyms Methotrexate disodium; MTX sodium;Sodium methotrexate;
Formula C20H20N8Na2O5 M. Wt 498.4
  • Biological Activity
Description Methotrexate Sodium is the sodium salt of methotrexate, an antimetabolite with antineoplastic and immunomodulating properties. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant properties.
Pathways Cell Cycle/DNA Damage Others Pathway 
Targets ADC Related DHFR 

Structure

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