DDD85646
| CAS No. | 1215010-55-1 | Cat. No. | BCP28646 |
| Name | DDD85646 | ||
| Synonyms | DDD-85646; DDD 85646; | ||
| Formula | C21H24Cl2N6O2S | M. Wt | 495.43 |
| Description | DDD85646 is a T. brucei N-myristoyltransferase (TbNMT) with an apparent Ki value of 1.44 nM. DDD85646 has potent activity against the enzyme (IC(50) = 2 nM) and T. brucei (EC(50) = 2 nM) in culture. DDD85646 has good oral pharmacokinetics and cures rodent models of peripheral HAT infection. DDD85646 provides an excellent tool for validation of T. brucei NMT as a drug target for HAT as well as a valuable lead for further optimization. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | DNA/RNA Synthesis | ||
Structure
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