Polmacoxib
| CAS号 | 301692-76-2 | 货号 | BCP15550 |
| 中文名 | Polmacoxib | ||
| 英文名 | Polmacoxib | ||
| 中文别名 | |||
| 英文别名 | CG100649; CG-100649; CG 100649; | ||
| 分子式 | C18H16FNO4S | 分子量 | 361.39 |
| 生物活性 | Polmacoxib, also known as CG100649, is a first-in-class NSAID drug candidate that is a dual inhibitor of COX-2 and carbonic anhydrase (CA). CG100649's interaction with CA in red blood cells provides it with a novel 'tissue-specific' transport mechanism that is designed to deliver sustained levels of drug to inflamed tissues, while maintaining low systemic exposure. Its unique dual COX-2 and CA binding properties are designed to provide potentially superior safety to cardiovascular, renal, and gastrointestinal tissues compared to traditional NSAIDs or COX-2 inhibitor drugs. CG100649 inhibits premalignant and malignant colorectal lesions in mouse models, partly through inhibiting tumor cell proliferation. | ||
| 信号通路 | Neuro Signaling Pathway | ||
| 靶 点 | COX | ||
结构式
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