Polmacoxib 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP15550CAS号：301692-76-2纯度：98%

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CAS号	301692-76-2	货号	BCP15550
中文名	Polmacoxib
英文名	Polmacoxib
中文别名
英文别名	CG100649; CG-100649; CG 100649;
SMILES	CC1(C(=O)C(=C(O1)C2=CC=C(C=C2)S(=O)(=O)N)C3=CC(=CC=C3)F)C
化学名称
分子式	C18H16FNO4S	分子量	361.39
纯度	98%	配送	惯例下常温包邮
产品描述	Polmacoxib, also known as CG100649, is a first-in-class NSAID drug candidate that is a dual inhibitor of COX-2 and carbonic anhydrase (CA). CG100649's interaction with CA in red blood cells provides it with a novel 'tissue-specific' transport mechanism that is designed to deliver sustained levels of drug to inflamed tissues, while maintaining low systemic exposure. Its unique dual COX-2 and CA binding properties are designed to provide potentially superior safety to cardiovascular, renal, and gastrointestinal tissues compared to traditional NSAIDs or COX-2 inhibitor drugs. CG100649 inhibits premalignant and malignant colorectal lesions in mouse models, partly through inhibiting tumor cell proliferation.