LY-2584702 对甲苯磺酸盐
| CAS号 | 1082949-68-5 | 货号 | BCP15576 |
| 中文名 | LY-2584702 对甲苯磺酸盐 | ||
| 英文名 | LY2584702 Tosylate | ||
| 中文别名 | |||
| 英文别名 | LY-2584702 Tosylate;LY 2584702 Tosylate;LY-2584702 tosylate salt; | ||
| 分子式 | C21H19F4N7.C7H8O3S | 分子量 | 617.62 |
| 生物活性 | LY-2584702 tosylate salt is an orally available inhibitor of p70S6K signaling; inhibits p70S6K and prevents phosphorylation of the S6 subunit of ribosomes.LY-2584702 is an orally available inhibitor of p70S6K signaling, with potential antineoplastic activity. LY2584702 inhibits ribosomal protein S6 Kinase (p70S6K), and prevents phosphorylation of the S6 subunit of ribosomes, thereby inhibiting normal ribosomal function within tumor cells leading to a decrease in protein synthesis and in cellular proliferation. P70S6K, a serine/threonine kinase, acts downstream of PIP3 and phosphoinositide-dependent kinase-1 in the PI3 kinase pathway, is often upregulated in a variety of cancer cells, and is involved in the regulation of cell growth, proliferation, motility, and survival. | ||
| 信号通路 | PI3K/Akt/mTOR MAPK Pathway | ||
| 靶 点 | RSK | ||
结构式
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