卢美哌隆
| CAS号 | 313368-91-1 | 货号 | BCP24038 |
| 中文名 | 卢美哌隆 | ||
| 英文名 | Lumateperone | ||
| 中文别名 | |||
| 英文别名 | ITI-722; ITI722; ITI 722; ITI-007; ITI007; ITI 007; | ||
| 分子式 | C24H28FN3O | 分子量 | 393.5 |
| 生物活性 | Lumateperone acts as a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a serotonin transporter blocker (Ki = 61 nM). It also possesses affinity for the D1 receptor (Ki = 52 nM) and lower affinity for the α1A- and α1B-adrenergic receptors (Ki = 73 nM at α1), 5-HT2C receptor (Ki = 173 nM), and D4 receptor.[6] Lumateperone does not significantly bind to the 5-HT2B, H1 (Ki > 1,000 nM), muscarinic acetylcholine receptors, or many other sites (Ki > 100 nM). | ||
| 信号通路 | Neuro Signaling Pathway GPCR/G Protein | ||
| 靶 点 | 5 HT Receptor/Serotonin Receptor Dopamine Receptor | ||
结构式
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