ABT594盐酸盐
| CAS号 | 203564-54-9 | 货号 | BCP25177 |
| 中文名 | ABT594盐酸盐 | ||
| 英文名 | Tebanicline HCl | ||
| 中文别名 | |||
| 英文别名 | Tebanicline hydrochloride;ABT594 HCl;Tebanicline; ABT-594; ABT 594; ABT594; Ebanicline; | ||
| 分子式 | C9H12Cl2N2O | 分子量 | 235.11 |
| 生物活性 | Tebanicline hydrochloride (ABT594 hydrochloride) is a nAChR modulator with potent, orally effective analgesic activity. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM.Tebanicline, also known as ABT-594 and Ebanicline, a potent synthetic nicotinic (non-opioid) analgesic drug developed by Abbott. It was developed as a less toxic analogue of the potent poison dart frog-derived compound epibatidine, which is some 200x stronger than morphine as an analgesic but produces extremely dangerous toxic side effects. Like epibatidine, tebanicline showed potent analgesic activity against neuropathic pain in both animal and human trials, but with far less toxicity than its parent compound. It acts as a partial agonist at neuronal nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes. | ||
| 上下游产品 | 198283-74-8（Tebanicline tosylate） 209326-18-1（Tebanicline dihydrochloride） 209326-18-1（Tebanicline benzoate） 198283-73-7（Tebanicline） | ||
| 信号通路 | Neuro Signaling Pathway | ||
| 靶 点 | nAChR | ||
结构式
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