ABT594盐酸盐

参考资料仅供科学研究，不可用于个人用途。

货号：BCP25177CAS号：203564-54-9纯度：98%

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CAS号	203564-54-9	货号	BCP25177
关联产品	198283-74-8（Tebanicline tosylate） 209326-18-1（Tebanicline dihydrochloride） 209326-18-1（Tebanicline benzoate） 198283-73-7（Tebanicline）
中文名	ABT594盐酸盐
英文名	Tebanicline HCl
中文别名
英文别名	Tebanicline hydrochloride;ABT594 HCl;Tebanicline; ABT-594; ABT 594; ABT594; Ebanicline;
SMILES
化学名称
分子式	C9H12Cl2N2O	分子量	235.11
纯度	98%	配送	惯例下常温包邮
产品描述	Tebanicline hydrochloride (ABT594 hydrochloride) is a nAChR modulator with potent, orally effective analgesic activity. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM.Tebanicline, also known as ABT-594 and Ebanicline, a potent synthetic nicotinic (non-opioid) analgesic drug developed by Abbott. It was developed as a less toxic analogue of the potent poison dart frog-derived compound epibatidine, which is some 200x stronger than morphine as an analgesic but produces extremely dangerous toxic side effects. Like epibatidine, tebanicline showed potent analgesic activity against neuropathic pain in both animal and human trials, but with far less toxicity than its parent compound. It acts as a partial agonist at neuronal nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes.