Givinostat
| CAS No. | 497833-27-9 | Cat. No. | BCP29856 |
| Name | Givinostat | ||
| Synonyms | Gavinostat; ITF-2357; ITF2357; ITF 2357; | ||
| Formula | C24H27N3O4 | M. Wt | 421.49 |
| Description | Givinostat or gavinostat, aslo known as ITF2357, is a potent and orally active histone deacetylase inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities. It is a hydroxamate used in the form of its hydrochloride. Inhibition of HDAC activity by ITF2357 ameliorates joint inflammation and prevents cartilage and bone destruction in experimental arthritis.ITF2357 reduces cytokines and protects islet β cells in vivo and in vitro. ITF2357 decreases surface CXCR4 and CCR5 expression on CD4(+) T-cells and monocytes and is superior to valproic acid for latent HIV-1 expression in vitro. | ||
| Pathways | Cell Cycle/DNA Damage Epigenetics | ||
| Targets | HDAC | ||
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.