MRX-2843
| CAS No. | 1429882-07-4 | Cat. No. | BCP30180 |
| Name | MRX-2843 | ||
| Synonyms | UNC2371;UNC-2371;UNC 2371;MRX 2843 ;MRX2843; | ||
| Formula | C29H40N6O | M. Wt | 488.68 |
| Description | MRX-2843 is a type 1 small-molecule tyrosine kinase inhibitor that abrogates activation of both MERTK and FLT3 and their downstream effectors. MRX-2843 treatment induces apoptosis and inhibits colony formation in AML cell lines and primary patient samples expressing MERTK and/or FLT3-ITD, with a wide therapeutic window compared with that of normal human cord blood cells. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | FLT3 | ||
Structure
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