INCB054329
| CAS No. | 1628607-64-6 | Cat. No. | BCP30303 |
| Name | INCB054329 | ||
| Synonyms | INCB-054329; INCB 054329; INCB54329; INCB 54329; INCB-54329; | ||
| Formula | C19H16N4O3 | M. Wt | 348.36 |
| Description | INCB054329, also known as INCB-54329, is a potent and selective BET protein inhibitor that targets BD1 and BD2 of BRD2, BRD3 and BRD4. In a panel of colon cancer cell lines, more than 50% are sensitive to INCB054329 treatment with IC50 values below 500 nM in cell proliferation assays. INCB054329 down-regulated c-Myc expression, and induced cell cycle arrest and apoptosis in sensitive colon cancer cell lines. Moreover, INCB54329 was efficacious in the RKO colon cancer xenograft model. INCB054329 as a single agent or in combination with other targeted therapies is potential useful for the treatment of colon cancer. | ||
| Pathways | Epigenetics | ||
| Targets | Epigenetic Reader Domain | ||
Structure
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