MA-0204
| CAS No. | 2095128-17-7 | Cat. No. | BCP30365 |
| Name | MA-0204 | ||
| Synonyms | MA 0204; MA0204; | ||
| Formula | C25H27F3N2O4 | M. Wt | 476.49 |
| Description | MA-0204 is a highly potent and selective PPARd modulator (PPARδ EC50 = 0.4 nM; PPARalpha, EC50 == 6,660 nM) that upregulates the expression of FAO genes in human renal proximal tubule cells, resulting in increased mitochondrial fatty acid oxidation. In normal rats undergoing IR-AKI, MA-0204 attenuates the increases of plasma and urinary biomarkers of AKI, improves renal function, mitigates proximal tubular damage and boosts mitochondrial gene expression. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | PPAR | ||
Structure
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