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CAS No. | 2095128-17-7 | Cat. No. | BCP30365 |
Name | MA-0204 | ||
Synonyms | MA 0204; MA0204; | ||
SMILES | CC1=CN=C(N1CC2=CC=CC=C2OCCCC(C)CC(=O)O)C3=CC=C(C=C3)OC(F)(F)F | ||
Chemical Name | |||
Formula | C25H27F3N2O4 | M. Wt | 476.49 |
Purity | 98% | Storage | Store at 4-8°C |
Description | MA-0204 is a highly potent and selective PPARd modulator (PPARδ EC50 = 0.4 nM; PPARalpha, EC50 == 6,660 nM) that upregulates the expression of FAO genes in human renal proximal tubule cells, resulting in increased mitochondrial fatty acid oxidation. In normal rats undergoing IR-AKI, MA-0204 attenuates the increases of plasma and urinary biomarkers of AKI, improves renal function, mitigates proximal tubular damage and boosts mitochondrial gene expression. |
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