RMC4550
| CAS No. | 2172651-73-7 | Cat. No. | BCP30530 |
| Name | RMC4550 | ||
| Synonyms | RMC 4550; RMC4550; | ||
| Formula | C21H26Cl2N4O2 | M. Wt | 437.36 |
| Description | RMC-4550 (RMC4550) is a potent, selective, allosteric inhibitor of SHP2 with IC50 of 0.58 nM (full-length SHP2 enzyme), suppresses pERK signaling in Calu-1 cells with IC50 of 7 nM; shows no activity against the SHP2 catalytic domain up to 10 uM, RMC-4550 is highly selective for full-length SHP2 across panels comprising 15 other phosphatases, 468 kinases, and 44 cellular targets; cancer cell lines bearing missense mutations in KRAS at G12, but neither G13 nor Q61, exhibit sensitivity to RMC-4550 (IC50<2 uM), suppresses growth and RAS/MAPK signaling in cancer cell lines with Class 3 BRAF mutations; inhibits tumor growth and RAS/MAPK signaling in xenograft models of KRASG12C-driven cancer. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | Phosphatase | ||
Structure
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