Nedisertib
| CAS No. | 1637542-33-6 | Cat. No. | BCP30542 |
| Name | Nedisertib | ||
| Synonyms | MSC2490484A; MSC-2490484A; MSC 2490484A; M3814; M-3814; M 3814; | ||
| Formula | C24H21ClFN5O3 | M. Wt | 481.91 |
| Description | Nedisertib, also known as M-3814, is an orally available inhibitor of DNA-dependent protein kinase (DNA-PK), with potential antineoplastic and chemo/radiosensitizing activities. Upon oral administration, the DNA-PK inhibitor MSC2490484A binds to and inhibits the activity of DNA-PK. This inhibits the ability of tumor cells to repair damaged DNA, which may lead to a reduction in cellular proliferation of cancer cells expressing DNA-PK. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | DNA PK | ||
Structure
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