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Nedisertib Chemical Structure

Nedisertib

Data Sheet For research use only. Not for human use.
Cat. No. :BCP30542CAS No. :1637542-33-6Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1637542-33-6 Cat. No. BCP30542
Name Nedisertib
Synonyms MSC2490484A; MSC-2490484A; MSC 2490484A; M3814; M-3814; M 3814;
SMILES COC1=NN=C(C=C1)C(C2=C(C=C(C(=C2)C3=NC=NC4=C3C=CC(=C4)N5CCOCC5)F)Cl)O
Chemical Name
Formula C24H21ClFN5O3 M. Wt 481.91
Purity 98% Storage Store at 4-8°C
Description Nedisertib, also known as M-3814, is an orally available inhibitor of DNA-dependent protein kinase (DNA-PK), with potential antineoplastic and chemo/radiosensitizing activities. Upon oral administration, the DNA-PK inhibitor MSC2490484A binds to and inhibits the activity of DNA-PK. This inhibits the ability of tumor cells to repair damaged DNA, which may lead to a reduction in cellular proliferation of cancer cells expressing DNA-PK.
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