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Torin 1 Chemical Structure

Torin 1

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP02504CAS No. ：1222998-36-8Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1222998-36-8 Cat. No. BCP02504
Name Torin 1
Synonyms Torin1;Torin-1;
SMILES
Chemical Name
Formula C35H28F3N5O2 M. Wt 607.64
Purity 98% Storage Store at 4-8°C
Description Torin1 inhibits phosphorylation of mTORC1 and mTORC2 substrates in cells at concentrations of 2 and 10 nM, respectively. Moreover, Torin1 exhibits 1000-fold selectivity for mTOR over PI3K (EC50 = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases.Torin1 causes cell cycle arrest through a rapamycin-resistant mechanism that is also independent of mTORC2. Torin1 disrupts mTORC1-dependent phenotypes more completely than rapamycin. Rapamycin-resistant functions of mTORC1 are required for cap-dependent translation.In a recent study, it is reported Torin1 increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON.
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H-NMR H-NMR HPLC
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