Pemigatinib
| CAS No. | 1513857-77-6 | Cat. No. | BCP31812 |
| Name | Pemigatinib | ||
| Synonyms | INCB054828; INCB-054828; INCB 054828; INCB54828; INCB 54828; INCB-54828; | ||
| Formula | C24H27F2N5O4 | M. Wt | 487.5 |
| Description | Pemigatinib is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) types 1, 2, and 3 (FGFR1/2/3), with potential antineoplastic activity. Pemigatinib binds to and inhibits FGFR1/2/3, which may result in the inhibition of FGFR1/2/3-related signal transduction pathways. This inhibits proliferation in FGFR1/2/3-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases upregulated in many tumor cell types, plays a key role in cellular proliferation, migration, and survival. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | FGFR | ||
Structure
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