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CAS No. | 1513857-77-6 | Cat. No. | BCP31812 |
Name | Pemigatinib | ||
Synonyms | INCB054828; INCB-054828; INCB 054828; INCB54828; INCB 54828; INCB-54828; | ||
SMILES | CCN1C2=C3C=C(NC3=NC=C2CN(C1=O)C4=C(C(=CC(=C4F)OC)OC)F)CN5CCOCC5 | ||
Chemical Name | |||
Formula | C24H27F2N5O4 | M. Wt | 487.5 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Pemigatinib is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) types 1, 2, and 3 (FGFR1/2/3), with potential antineoplastic activity. Pemigatinib binds to and inhibits FGFR1/2/3, which may result in the inhibition of FGFR1/2/3-related signal transduction pathways. This inhibits proliferation in FGFR1/2/3-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases upregulated in many tumor cell types, plays a key role in cellular proliferation, migration, and survival. |
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