AUY954
| CAS No. | 820240-77-5 | Cat. No. | BCP33492 |
| Name | AUY954 | ||
| Synonyms | NVP-AUY954;AUY-954;AUY 954; | ||
| Formula | C25H20F3NO2S | M. Wt | 455.49 |
| Description | AUY-954 is a potent and selective S1P(1) modulator. AUY-954 prevents experimental autoimmune neuritis. In EAN rats, AUY954 greatly prevented paraparesis if administrated from the day of immunization. T cell, B cell, and macrophage infiltration, inflammatory demyelination, and local expression of interleukine-17 and matrix metalloproteinase-9 in sciatic nerves of EAN rats were significantly decreased by AUY954 treatment. Therefore, S1P(1) modulation might be a potential treatment option for inflammatory neuropathies. | ||
| Pathways | GPCR/G Protein | ||
| Targets | S1P Receptor | ||
Structure
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