AUY954 New
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| CAS No. | 820240-77-5 | Cat. No. | BCP33492 |
| Name | AUY954 | ||
| Synonyms | NVP-AUY954;AUY-954;AUY 954; | ||
| SMILES | C1=CC=C(C=C1)C2=C(C=C(C=C2)C3=CC4=C(S3)C=CC(=C4)CNCCC(=O)O)C(F)(F)F | ||
| Chemical Name | |||
| Formula | C25H20F3NO2S | M. Wt | 455.49 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | AUY-954 is a potent and selective S1P(1) modulator. AUY-954 prevents experimental autoimmune neuritis. In EAN rats, AUY954 greatly prevented paraparesis if administrated from the day of immunization. T cell, B cell, and macrophage infiltration, inflammatory demyelination, and local expression of interleukine-17 and matrix metalloproteinase-9 in sciatic nerves of EAN rats were significantly decreased by AUY954 treatment. Therefore, S1P(1) modulation might be a potential treatment option for inflammatory neuropathies. | ||
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