Opelconazole
| CAS No. | 1931946-73-4 | Cat. No. | BCP36481 |
| Name | Opelconazole | ||
| Synonyms | PC 945;PC-945;PC945; | ||
| Formula | C38H37F3N6O3 | M. Wt | 682.73 |
| Description | PC945 is a novel broad spectrum antifungal agent that potently inhibits Aspergillus fumigatus sterol 14α-demethylase (CYP51A and CYP51B) with IC50 of 0.23 and 0.22 uM, respectively; shows MIC values 0.032 to >8 ug/ml against 96 clinically isolated A. fumigatus strains, demonstrates activity against itraconazole-susceptible and -resistant A. fumigatus growth with IC50 of 0.0012 to 0.034 ug/ml; PC945 is a broad spectrum of pathogenic fungi with MIC 0.0078 to 2 ug/ml, and exhibits activity in vivo. | ||
| Pathways | Protease/Metabolic Enzyme Microbiology/Virology | ||
| Targets | Cytochrome P450 Antifungal | ||
Structure
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