3'-O-methylguanosine

CAS No.	10300-27-3	Cat. No.	BCP38465
Name	3'-O-methylguanosine
Synonyms	3'-O-methyl-Guanosine;Guanosine, 3'-O-methyl-;3-OMG;
Formula	C11H15N5O5	M. Wt	297.27

Description	3'-O-Methylguanosine is an endogenous methylated nucleoside found in human fluids. Methylated purine bases are present in higher amounts in tumor-bearing patients compared to healthy controls. DNA hypermethylation is a common finding in malignant cells and has been explored as a therapeutic target for hypomethylating agents. When chemical bonds to DNA, it becomes damaged and proper and complete replication cannot occur to make the normal intended cell. A DNA adduct is an abnormal piece of DNA covalently-bonded to a cancer-causing chemical. This has shown to be the start of a cancerous cell, or carcinogenesis. DNA adducts in scientific experiments are used as bio-markers and as such are themselves measured to reflect quantitatively, for comparison, the amount of cancer in the subject.
Pathways	Cell Cycle/DNA Damage
Targets	DNA/RNA Synthesis

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