3'-O-methylguanosine New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 10300-27-3 | Cat. No. | BCP38465 |
| Name | 3'-O-methylguanosine | ||
| Synonyms | 3'-O-methyl-Guanosine;Guanosine, 3'-O-methyl-;3-OMG; | ||
| SMILES | COC1C(OC(C1O)N2C=NC3=C2N=C(NC3=O)N)CO | ||
| Chemical Name | |||
| Formula | C11H15N5O5 | M. Wt | 297.27 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | 3'-O-Methylguanosine is an endogenous methylated nucleoside found in human fluids. Methylated purine bases are present in higher amounts in tumor-bearing patients compared to healthy controls. DNA hypermethylation is a common finding in malignant cells and has been explored as a therapeutic target for hypomethylating agents. When chemical bonds to DNA, it becomes damaged and proper and complete replication cannot occur to make the normal intended cell. A DNA adduct is an abnormal piece of DNA covalently-bonded to a cancer-causing chemical. This has shown to be the start of a cancerous cell, or carcinogenesis. DNA adducts in scientific experiments are used as bio-markers and as such are themselves measured to reflect quantitatively, for comparison, the amount of cancer in the subject. | ||
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