XL177A
| CAS No. | 2417089-74-6 | Cat. No. | BCP40918 |
| Name | XL177A | ||
| Synonyms | XL-177A; XL 177A; | ||
| Formula | C48H57ClN8O5 | M. Wt | 861.47 |
| Description | XL177A is a potent USP7 inhibitor. XL177A irreversibly inhibits USP7 with sub-nM potency and selectivity across the human proteome. Evaluation of the cellular effects of XL177A reveals that selective USP7 inhibition suppresses cancer cell growth predominantly through a p53-dependent mechanism: XL177A specifically upregulates p53 transcriptional targets transcriptome-wide, hotspot mutations in TP53 but not any other genes predict response to XL177A across a panel of ~500 cancer cell lines, and TP53 knockout rescues XL177A-mediated growth suppression of TP53 wild-type (WT) cells. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | DUB | ||
Structure
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