XL177A New
Data Sheet
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| CAS No. | 2417089-74-6 | Cat. No. | BCP40918 |
| Name | XL177A | ||
| Synonyms | XL-177A; XL 177A; | ||
| SMILES | O=C(NC1=CC(N=CN2CC3(O)CCN(C([C@H](CC4=CC=CC=C4)CCCNC(C5=CC(N=C(CCCC6)C6=C7Cl)=C7C=C5)=O)=O)CC3)=C(C=C1)C2=O)CCN8CCN(C)CC8 | ||
| Chemical Name | |||
| Formula | C48H57ClN8O5 | M. Wt | 861.47 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | XL177A is a potent USP7 inhibitor. XL177A irreversibly inhibits USP7 with sub-nM potency and selectivity across the human proteome. Evaluation of the cellular effects of XL177A reveals that selective USP7 inhibition suppresses cancer cell growth predominantly through a p53-dependent mechanism: XL177A specifically upregulates p53 transcriptional targets transcriptome-wide, hotspot mutations in TP53 but not any other genes predict response to XL177A across a panel of ~500 cancer cell lines, and TP53 knockout rescues XL177A-mediated growth suppression of TP53 wild-type (WT) cells. | ||
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