RA-9 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 919091-63-7 | Cat. No. | BCP48946 |
| Name | RA-9 | ||
| Synonyms | RA 9; RA9; RA-9 UPS inhibitor; | ||
| SMILES | C1C(=CC2=CC=C(C=C2)[N+](=O)[O-])C(=O)C(=CC3=CC=C(C=C3)[N+](=O)[O-])CN1 | ||
| Chemical Name | |||
| Formula | C19H15N3O5 | M. Wt | 365.34 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | RA-9 is a potent and selective proteasome-associated deubiquitinating enzymes (DUBs) inhibitor with favorable toxicity profile and anticancer activity. RA-9 blocks ubiquitin-dependent protein degradation without impacting 20S proteasome proteolytic activity. RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors. RA-9 induces endoplasmic reticulum (ER)-stress responses in ovarian cancer cells. | ||
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