HBX19818 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP40268CAS No. ：1426944-49-1Purity：98%

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CAS No.	1426944-49-1	Cat. No.	BCP40268
Name	HBX19818
Synonyms	HBX-19818; HBX 19818;
SMILES	CN(CCCNC(=O)C1=CC2=C(C=C1)N=C3CCCCC3=C2Cl)CC4=CC=CC=C4
Chemical Name
Formula	C25H28ClN3O	M. Wt	421.96
Purity	98%	Storage	Store at 4-8°C
Description	HBX19818 exhibited a dose-dependent effect on USP7 activity. HBX 19,818 efficiently blocked labeling of USP7 but not that of USP8, USP5, USP10, CYLD, or UCH-L3, showing this compound's specificity for USP7 over a panel of active DUBs under physiological conditions proved to be active in cells, as it almost completely inhibited USP7 labeling at 25 mM. MS/MS spectrum revealed that HBX 19,818 is attached to Cys315. Based on UV chromatogram (l = 332 nm) peak areas, HBX 19,818 partially reverses the deubiquitination of Mdm2 by USP7 in HEK293 cells, confirming that HBX 19,818 inhibits a biological activity of USP7 in living cells. HBX 19,818 has additional off-target, p53-independent proapoptotic effects.