Hexamethyleneamiloride
| CAS No. | 1428-95-1 | Cat. No. | BCP41883 |
| Name | Hexamethyleneamiloride | ||
| Synonyms | 5-(N,N-Hexamethylene)amiloride; HMA; | ||
| Formula | C12H18ClN7O | M. Wt | 311.77 |
| Description | Hexamethyleneamiloride derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. It is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively. | ||
| Pathways | Microbiology/Virology | ||
| Targets | HIV | ||
Structure
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