ZX-29
| CAS No. | 2254805-62-2 | Cat. No. | BCP45485 |
| Name | ZX-29 | ||
| Synonyms | ZX 29;ZX29; | ||
| Formula | C23H28ClN7O3S | M. Wt | 518.03 |
| Description | ZX-29 is a potent and selective ALK inhibitor for ALK, ALK L1196M and ALK G1202R mutations, respectively. ZX-29 is inactive against EGFR. ZX-29 induces apoptosis by inducing endoplasmic reticulum (ER) stress and overcomes cell resistance caused by an ALK mutation. ZX-29 also induces protective autophagy and has antitumor effect. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | ALK | ||
Structure
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