JNJ 10191584 maleate
| CAS No. | 869497-75-6 | Cat. No. | BCP48110 |
| Name | JNJ 10191584 maleate | ||
| Synonyms | JNJ10191584 maleate;JNJ-10191584 maleate;JNJ 10191584 maleate salt;VUF 6002 maleate;VUF6002 maleate; | ||
| Formula | C17H19ClN4O5 | M. Wt | 394.81 |
| Description | JNJ 10191584 maleate is a highly selective histamine H4 receptor silent antagonist; binds with high affinity to the human H4 receptor (Ki = 26 nM). > 540-fold selective over the H3 receptor (Ki = 14.1 μM). Inhibits mast cell and eosinophil chemotaxis in vitro with IC50 values of 138 and 530 nM respectively. Orally active in vivo. | ||
| Related Products | 73903-17-0（JNJ 10191584） | ||
| Pathways | Neuro Signaling Pathway GPCR/G Protein | ||
| Targets | Histamine Receptor | ||
Structure
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