JNJ 10191584 maleate New
Data Sheet
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| CAS No. | 869497-75-6 | Cat. No. | BCP48110 |
| Related Products | 73903-17-0（JNJ 10191584） | ||
| Name | JNJ 10191584 maleate | ||
| Synonyms | JNJ10191584 maleate;JNJ-10191584 maleate;JNJ 10191584 maleate salt;VUF 6002 maleate;VUF6002 maleate; | ||
| SMILES | CN1CCN(CC1)C(=O)C2=NC3=C(N2)C=C(C=C3)Cl.C(=CC(=O)O)C(=O)O | ||
| Chemical Name | |||
| Formula | C17H19ClN4O5 | M. Wt | 394.81 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | JNJ 10191584 maleate is a highly selective histamine H4 receptor silent antagonist; binds with high affinity to the human H4 receptor (Ki = 26 nM). > 540-fold selective over the H3 receptor (Ki = 14.1 μM). Inhibits mast cell and eosinophil chemotaxis in vitro with IC50 values of 138 and 530 nM respectively. Orally active in vivo. | ||
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