VE-822
  • 化学数据
CAS号 1232416-25-9 货号 BCP07948
中文名 VE-822
英文名 VE-822
中文别名
英文别名 VE822; VE 822; VX970; VX-970; VX 970; Berzosertib;
分子式 C24H25N5O3S 分子量 463.55
  • 用途
生物活性 VE-822, also known as VX-970 or Berzosertib, is an potent ATR inhibitor. VE-822 inhibited ATR in vitro and in vivo. VE-822 decreased maintenance of cell-cycle checkpoints, increased persistent DNA damage and decreased homologous recombination in irradiated cancer cells. VE-822 decreased survival of pancreatic cancer cells but not normal cells in response to XRT or gemcitabine. VE-822 markedly prolonged growth delay of pancreatic cancer xenografts after XRT and gemcitabine-based chemoradiation without augmenting normal cell or tissue toxicity. These findings support ATR inhibition as a promising new approach to improve the therapeutic ration of radiochemotherapy for patients with PDAC.
信号通路 Cell Cycle/DNA Damage PI3K/Akt/mTOR 
靶 点 ATM/ATR 

结构式

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