Tipiracil HCl
| CAS No. | 183204-72-0 | Cat. No. | BCP06245 |
| Name | Tipiracil HCl | ||
| Synonyms | TAS-1-462; MA-1;Tipiracil hydrochloride;TPI; TAS-102; | ||
| Formula | C9H11ClN4O2.HCl | M. Wt | 279.12 |
| Description | Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.Tipiralacil, also known as TPI, is a thymidine phosphorylase inhibitor (TPI). Tipiracil is one of the active components in TAS-102, which is an anticancer drug candidate currently in clinical trials. TAS-102 consists of the cytotoxin Trifluridine and the thymidine phosphorylase inhibitor (TPI) tipiracil. Trifluridine is incorporated into DNA during DNA synthesis and inhibits tumor cell growth. Tipiracil protects trifluridine from being broken down when taken orally. TAS-102 was approved in Japan in 2015. | ||
| Related Products | 183204-74-2（Tipiracil） 733030-01-8（Trifluridine-tipiracil hydrochloride mixture） | ||
| Pathways | Cell Cycle/DNA Damage Apoptosis Pathway | ||
| Targets | Thymidylate Synthase Antimetabolite | ||
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Panitumumab interaction with TAS‐102 leads to combinational anticancer effects via blocking of EGFR‐mediated tumor response to trifluridine
Publications Citing of Biochempartner's Tipiracil HCl(CAS:183204-72-0) |
Structure
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