Bendamustine

CAS No.	16506-27-7	Cat. No.	BCP04111
Name	Bendamustine
Synonyms	Bendamustine free base; SDX105; SDX 105; SDX-105; DD6304600; Bendamustinum; Bendamustina; Ribomustin;
Formula	C16H21Cl2N3O2	M. Wt	358.26

Description	Bendamustine is a bifunctional mechlorethamine derivative with alkylator and antimetabolite activities. Bendamustine possesses three active moieties: an alkylating group; a benzimidazole ring, which may act as a purine analogue; and a butyric acid side chain. Although its exact mechanism of action is unknown, this agent appears to act primarily as an alkylator. Bendamustine metabolites alkylate and crosslink macromolecules, resulting in DNA, RNA and protein synthesis inhibition, and, subsequently, apoptosis. In October 2008, the FDA granted further approval to market Treanda for the treatment of indolent B-cell non-Hodgkin's lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen.
Related Products	3543-75-7（Bendamustine HCl）
Pathways	Cell Cycle/DNA Damage
Targets	DNA Alkylator/Crosslinker

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