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Bendamustine Chemical Structure

Bendamustine

Data Sheet For research use only. Not for human use.
Cat. No. :BCP04111CAS No. :16506-27-7Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 16506-27-7 Cat. No. BCP04111
Related Products 3543-75-7(Bendamustine HCl)
Name Bendamustine
Synonyms Bendamustine free base; SDX105; SDX 105; SDX-105; DD6304600; Bendamustinum; Bendamustina; Ribomustin;
SMILES
Chemical Name
Formula C16H21Cl2N3O2 M. Wt 358.26
Purity 98% Storage Store at 4-8°C
Description Bendamustine is a bifunctional mechlorethamine derivative with alkylator and antimetabolite activities. Bendamustine possesses three active moieties: an alkylating group; a benzimidazole ring, which may act as a purine analogue; and a butyric acid side chain. Although its exact mechanism of action is unknown, this agent appears to act primarily as an alkylator. Bendamustine metabolites alkylate and crosslink macromolecules, resulting in DNA, RNA and protein synthesis inhibition, and, subsequently, apoptosis. In October 2008, the FDA granted further approval to market Treanda for the treatment of indolent B-cell non-Hodgkin's lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen.
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