Agomelatine
| CAS No. | 138112-76-2 | Cat. No. | BCP02084 |
| Name | Agomelatine | ||
| Synonyms | Valdoxan;Melitor;Thymanax; | ||
| Formula | C15H17NO2 | M. Wt | 243.3 |
| Description | Agomelatine is an antidepressant drug. It is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. Activation of 5-HT2C receptors by serotonin inhibits dopamine and norepinephrine release. Antagonism of 5-HT2C results in an enhancement of DA and NE release and activity of frontocortical dopaminergic and adrenergic pathways. Agomelatine is also a potent agonist at melatonin receptors which makes it the first melatonergic antidepressant. | ||
| Pathways | Neuro Signaling Pathway GPCR/G Protein | ||
| Targets | 5 HT Receptor/Serotonin Receptor Melatonin Receptor | ||
Structure
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