Bendamustine HCl

  • Chemical Properties
CAS No. 3543-75-7 Cat. No. BCP02107
Name Bendamustine HCl
Synonyms Bendamustine hydrochloride; Ribomustin;SDX-105;SDX 105;SDX105; EP-3101; EP 3101; EP3101;
Formula C16H22Cl3N3O2 M. Wt 394.72
  • Biological Activity
Description Bendamustine hydrochloride is the hydrochloride salt of bendamustine, a bifunctional mechlorethamine derivative with alkylator and antimetabolite activities. Bendamustine possesses three active moieties: an alkylating group; a benzimidazole ring, which may act as a purine analogue; and a butyric acid side chain. Although its exact mechanism of action is unknown, this agent appears to act primarily as an alkylator. Bendamustine metabolites alkylate and crosslink macromolecules, resulting in DNA, RNA and protein synthesis inhibition, and, subsequently, apoptosis. In October 2008, the FDA granted further approval to market Treanda for the treatment of indolent B-cell non-Hodgkin's lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen.
Related Products 16506-27-7(Bendamustine)
Pathways Cell Cycle/DNA Damage 
Targets DNA Alkylator/Crosslinker 

Structure

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