6-Thioguanine

  • Chemical Properties
CAS No. 154-42-7 Cat. No. BCP27718
Name 6-Thioguanine
Synonyms Thioguanine;6-TG; 2-Amino-6-mercaptopurine; 2-Amino-6-purinethiol;
Formula C5H5N5S M. Wt 167.19
  • Biological Activity
Description 6-Thioguanine is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC50s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.
Pathways Microbiology/Virology Cell Cycle/DNA Damage 
Targets SARS CoV DUB 

Structure

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