Pralatrexate

CAS No.	146464-95-1	Cat. No.	BCP02025
Name	Pralatrexate
Synonyms	Folotyn;10-Propargyl-10-deazaaminopterin;
Formula	C23H23N7O5	M. Wt	477.47

Description	Pralatrexate is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1; intracellularly, this agent is highly polyglutamylated and competes for the folate binding site of DHFR, blocking tetrahydrofolate synthesis, which may result in depletion of nucleotide precursors; inhibition of DNA, RNA and protein synthesis; and apoptotic tumor cell death.
Pathways	Cell Cycle/DNA Damage
Targets	DHFR

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