Alectinib Hydrochloride
| CAS No. | 1256589-74-8 | Cat. No. | BCP09075 |
| Name | Alectinib Hydrochloride | ||
| Synonyms | CH-5428402 HCl; AF-802 Hydrochloride; RG-7853 Hydrochloride; RO-5424802 Hydrochloride; | ||
| Formula | C30H35ClN4O2 | M. Wt | 519.08 |
| Description | Alectinib Hydrochloride (CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride) is a potent, selective, and orally available ALK inhibitor with IC50 of 1.9 nM, the dissociation constant (KD) value for ALK in an ATP-competitive manner is 2.4 nM using a competition-bind assay.Alectinib, also known as AF802, or CH5424802 or RO5424802, is a potent, selective, and orally available ALK inhibitor with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK, such as nonsmall cell lung cancer (NSCLC) cells expressing EML4-ALK fusion and anaplastic large-cell lymphoma (ALCL) cells expressing NPM-ALK fusion in vitro and in vivo. Alectinib inhibited ALK L1196M, which corresponds to the gatekeeper mutation conferring common resistance to kinase inhibitors, and blocked EML4-ALK L1196M-driven cell growth. | ||
| Related Products | 1256580-46-7（Alectinib） | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | ALK | ||
Structure
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