ME-0328
| CAS No. | 1445251-22-8 | Cat. No. | BCP28104 |
| Name | ME-0328 | ||
| Synonyms | ME0328; ME 0328; | ||
| Formula | C19H19N3O2 | M. Wt | 321.38 |
| Description | ME0328 is an inhibitor of PARP-3 (IC50 = 0.89 μM). ME0328 displays selectivity for PARP-3 over PARP-1, PARP-2 and other ARDT enzymes (IC50 values are 6.3, 10.8 and >30 μM respectively). ME0328 also enhances CRISPR-Cas9-mediated HER2 mutation frequency, resulting in increased reduction in proliferation of HER2-positive breast cancer cells. | ||
| Pathways | Cell Cycle/DNA Damage Epigenetics | ||
| Targets | PARP | ||
Structure
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