Jervine
| CAS No. | 469-59-0 | Cat. No. | BCP28214 |
| Name | Jervine | ||
| Synonyms | 11-Ketocyclopamine; | ||
| Formula | C27H39NO3 | M. Wt | 425.61 |
| Description | Jervine, coming from the herbs of Veratrum nigrum L, has antibacterial properties. Jervine demonstrates teratogenic properties. It is the starting material for C-nor-D-homosteroids. Jervine induces holoprosencephaly and blocks endogenous Sonic hedgehog signaling.Jervine binds with and inhibits smoothened, which is an integral part of the hedgehog signaling pathways. | ||
| Pathways | GPCR/G Protein Wnt/Stem Cell | ||
| Targets | Smoothened/Smo Hedgehog | ||
Structure
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