Trovafloxacin

Description	Trovafloxacin was a broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was withdrawn from the market due to the risk of hepatotoxicity. It had better gram-positive bacterial coverage and less gram-negative coverage than the previous fluoroquinolones.
Pathways	Microbiology/Virology Cell Cycle/DNA Damage
Targets	Topoisomerase Antibiotic

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