Cucurbitacin b
| CAS No. | 6199-67-3 | Cat. No. | BCP13825 |
| Name | Cucurbitacin b | ||
| Synonyms | Cuc B; NSC 49451; NSC 144154;NSC-49451; NSC-144154;NSC49451; NSC144154; | ||
| Formula | C32H46O8 | M. Wt | 558.7 |
| Description | Cucurbitacin B is a plant-derived triterpene that has the classic four-ring structure of mammalian steroids. Cucurbitacin B suppresses metastasis mediated by reactive oxygen species (ROS) via focal adhesion kinase (FAK) in breast cancer MDA-MB-231 cells. Cucurbitacin B induces inhibitory effects via CIP2A/PP2A/Akt pathway in glioblastoma multiforme. Cucurbitacin B acts a potential insect growth regulator by antagonizing 20-hydroxyecdysone activity. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase Cell Cycle/DNA Damage | ||
| Targets | Integrin CDK | ||
Structure
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