SAR-260301
| CAS No. | 1260612-13-2 | Cat. No. | BCP13808 |
| Name | SAR-260301 | ||
| Synonyms | SAR 260301;SAR260301; | ||
| Formula | C19H22N4O3 | M. Wt | 354.40 |
| Description | SAR260301 is potent and selective Class I phosphatidylinositol-3-kinase (PI3K)β specific inhibitor with an IC50 of 52 nM for this isoform. SAR260301 is being investigated for the treatment of PTEN-deficient tumors. SAR260301 displayed improved physicochemical and in vitro pharmacokinetic properties. SAR260301 demonstrated significant in vivo activity in a UACC-62 xenograft model in mice, warranting further preclinical investigation. | ||
| Pathways | PI3K/Akt/mTOR | ||
| Targets | PI3K | ||
Structure
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