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SAR-260301 Chemical Structure

SAR-260301

Data Sheet For research use only. Not for human use.
Cat. No. :BCP13808CAS No. :1260612-13-2Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1260612-13-2 Cat. No. BCP13808
Name SAR-260301
Synonyms SAR 260301;SAR260301;
SMILES CC1CC2=CC=CC=C2N1C(=O)CC3=NC(=O)C=C(N3)N4CCOCC4
Chemical Name
Formula C19H22N4O3 M. Wt 354.40
Purity 98% Storage Store at 4-8°C
Description SAR260301 is potent and selective Class I phosphatidylinositol-3-kinase (PI3K)β specific inhibitor with an IC50 of 52 nM for this isoform. SAR260301 is being investigated for the treatment of PTEN-deficient tumors. SAR260301 displayed improved physicochemical and in vitro pharmacokinetic properties. SAR260301 demonstrated significant in vivo activity in a UACC-62 xenograft model in mice, warranting further preclinical investigation.
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