TX-1918
| CAS号 | 503473-32-3 | 货号 | BCP16358 |
| 中文名 | TX-1918 | ||
| 英文名 | TX-1918 | ||
| 中文别名 | |||
| 英文别名 | TX 1918;TX1918; | ||
| 分子式 | C14H12O3 | 分子量 | 228.24 |
| 生物活性 | TX-1918 is a cell-permeable tyrphostin derivative that inhibits eukaryotic elongation factor-2 kinase (eEF-2K; IC50 = 440 nM). It inhibits Src, PKA, PKC, and EGFR kinases at much higher concentrations (IC50s = 4.4, 44, 44, and 440 µM, respectively).TX-1918 disrupts the proliferation of HepG2 and HCT116 tumor cells (EC50s = 2.07 and 230 µM, respectively) with ≥5,000-fold and ≥90-fold reduced mitochondrial- and hepato-toxicity, respectively when compared with the tyrphostin AG-17. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway GPCR/G Protein TGF beta/Smad Wnt/Stem Cell Epigenetics | ||
| 靶 点 | Src/Bcr Abl EGFR PKA PKC | ||
结构式
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