NSC-12
| CAS No. | 102586-30-1 | Cat. No. | BCP24324 |
| Name | NSC-12 | ||
| Synonyms | NSC 12; NSC12; NSC 172285; NSC-172285; NSC172285; | ||
| Formula | C24H34F6O3 | M. Wt | 484.52 |
| Description | NSC-12, also known as NSC 172285, is an extracellular FGF trap with significant implications in cancer therapy. NSC12 inhibited the proliferation of different FGF-dependent tumour cell lines, but had no inhibitory effect on FGF-independent tumour cells expressing a constitutively active FGFR1. In vivo, NSC12 was shown to inhibit FGFR phosphorylation, angiogenesis and primary and metastatic tumour growth of FGF-dependent human and mouse cancer cells. Importantly, there was no systemic toxic effect. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | FGFR | ||
Structure
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